Submit Manuscript  

Article Details

The Chemistry of the Canthin-4-ones

[ Vol. 14 , Issue. 2 ]


Franz Bracher* and Tim Tremmel   Pages 92 - 98 ( 7 )


Background: The canthin-4-ones are a small, yet underexplored class of natural products from Apocynaceae plants. Efficient synthetic approaches are required for exploring this class of natural products for drug discovery.

Objective: In this review, the synthetic approaches towards these alkaloids, as well as synthetic analogues are summarized comprehensively. Further, the applications of canthin-4-ones as building blocks for the synthesis of alkaloids and other polycyclic compounds of pharmaceutical interest are demonstrated.

Conclusion: Meanwhile, efficient and flexible approaches to the canthin-4-one scaffold are available which should foster in-depth investigation of this chemotype for drug development.


Canthin-4-ones, alkaloids, total synthesis, β-carbolines, ring transformation, biological activity.


Department of Pharmacy, Ludwig-Maximilians University, Butenandtstr. 5-13, 81377 Munich, Department of Pharmacy, Center for Drug Research, Ludwig-Maximilians University, Munich

Graphical Abstract:

Read Full-Text article