Submit Manuscript  

Article Details


New Progress in Asymmetric Synthesis of Quaternary α-Amino Acids

[ Vol. 14 , Issue. 6 ]

Author(s):

Han Jiang, Yi Jin* and Jun Lin*   Pages 434 - 447 ( 14 )

Abstract:


Background: Quaternary α-amino acids with a tetrasubstituted carbon stereocenter have a variety of biological activities. Due to the steric hindrance of the quaternary carbon centers, highly efficient asymmetric catalytic synthesis is greatly challenging.

Objective: In this paper, with a focus on the asymmetric formation of chemical bonds in reactions, the asymmetric catalytic synthesis of quaternary α-amino acids in recent years is reviewed.

Conclusion: Several representative catalytic asymmetric reactions are introduced, and the effects of different catalysts on the reaction results are discussed.

Keywords:

Quaternary a-amino acids, asymmetric catalytic synthesis, quaternary stereocenters, formation of C-C bond, formation of C-N bond, asymmetric alkylation reaction.

Affiliation:

Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University), Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, P.R., Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University), Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, P.R., Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University), Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, P.R.

Graphical Abstract:



Read Full-Text article