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Bioactive Flavonoids from Cornus mas L. Fruits

[ Vol. 14 , Issue. 6 ]


Bianca Moldovan* and Luminita David   Pages 489 - 495 ( 7 )


Background: Cornus mas L. is a small tree of the Cornaceae plant family, widely spread in South Eastern Europe and Asia. The fruits of Cornus mas L. have been reported to possess anti-inflammatory, cardioand hepatoprotective, cytotoxic, antibacterial, antigenotoxic and diuretic effects. A high number of bioactive compounds have been identified in Cornus mas fruits, among which flavonoids exert favorable health effects especially by acting as potent antioxidants.

Method: The main step in the isolation of flavonoids from vegetal matrices is extraction. Apart the usually applied methods of organic compounds characterization like mass spectrometry (MS), ultraviolet and visible (UV-Vis) and infrared (IR) spectroscopy, the advanced analytical techniques such as high performance liquid chromatography (HPLC) and nuclear magnetic resonance (NMR) are reliable tools in flavonoids structure determination.

Conclusion: This review focuses on the recent published studies regarding the extraction, characterization and biological activities of flavonoids isolated from these fruits in order to understand their high potential as a source of bioactive compounds and their importance in developing new pharmacological products.


Cornus mas, Cornelian cherries, flavonoids, extraction, chalcone synthase, biological activity.


Department of Chemistry, Faculty of Chemistry and Chemical Engineering, “Babes-Bolyai” University, Cluj-Napoca, Department of Chemistry, Faculty of Chemistry and Chemical Engineering, “Babes-Bolyai” University, Cluj-Napoca

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