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A Mini Review on Synthetic Approaches and Biological Activities of Benzodiazepines

[ Vol. 14 , Issue. 6 ]


Shweta Verma* and Sushil Kumar   Pages 453 - 468 ( 16 )


Background: Benzodiazepines (BDZs) are the bicyclic heterocyclic compounds in which benzene ring is fused to seven membered ring containing two nitrogen atoms. There are different types of BDZs such as 1, 2-benzodiazepines, 1, 3-benzodiazepines, 1, 4-benzodiazepines, 1, 5-benzodiazepines- 2, 3-benzodiazepines possess anxiolytic, anticonvulsant, antipsychotics, muscle relaxant and antimicrobial activities.

Method: Modifications and substitutions have been made in both rings by employing different methods to obtain a large number of BDZs. Due to their biological potentials the benzodiazepine nucleus has continued to attract many investigators to synthesize and screen their analogues for all possible biological activities.

Conclusion: This current review article describes the synthetic approaches and biological activities of benzodiazepines.


Benzodiazepines, scaffold, bioactive, skeleton


Faculty of Pharmacy, IFTM University, Moradabad, 24400, Faculty of Pharmacy, IFTM University, Moradabad, 24400

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