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A Mini Review on Synthetic Approaches and Biological Activities of Benzodiazepines

[ Vol. 14 , Issue. 6 ]

Author(s):

Shweta Verma* and Sushil Kumar   Pages 453 - 468 ( 16 )

Abstract:


Background: Benzodiazepines (BDZs) are the bicyclic heterocyclic compounds in which benzene ring is fused to seven membered ring containing two nitrogen atoms. There are different types of BDZs such as 1, 2-benzodiazepines, 1, 3-benzodiazepines, 1, 4-benzodiazepines, 1, 5-benzodiazepines- 2, 3-benzodiazepines possess anxiolytic, anticonvulsant, antipsychotics, muscle relaxant and antimicrobial activities.

Method: Modifications and substitutions have been made in both rings by employing different methods to obtain a large number of BDZs. Due to their biological potentials the benzodiazepine nucleus has continued to attract many investigators to synthesize and screen their analogues for all possible biological activities.

Conclusion: This current review article describes the synthetic approaches and biological activities of benzodiazepines.

Keywords:

Benzodiazepines, scaffold, bioactive, skeleton

Affiliation:

Faculty of Pharmacy, IFTM University, Moradabad, 24400, Faculty of Pharmacy, IFTM University, Moradabad, 24400

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