Submit Manuscript  

Article Details


Flavonoids as Multi-Target Compounds in Drug Discovery

[ Vol. 14 , Issue. 4 ]

Author(s):

L. Scotti*, H. Ishiki, F.J.B. Mendonça Júnior, R.M.D. Cruz, J.F. Tavares, M.F.F.M. Diniz, J.M. Barbosa Filho and M.T. Scotti   Pages 333 - 341 ( 9 )

Abstract:


With the aim of offering patients a more effective drug therapy and with few side effects, it was believed in the perfect and unique interaction of the bioactive compound and the receptor or target macromolecule. This concept has changed, and multifunctional compounds show greater efficiency, particularly in the therapy of complex diseases, with a sum of origin. Among these ills, we quote: neurodegenerative diseases, cancer, parasitic and inflammatory. To fight these diseases, studies with multitarget flavonoids have been reported. Flavonoid compounds are natural products traditionally used as chemotherapy because of their numerous therapeutic activities. Here, we gather studies with multitarget in drug discovery flavonoids.

Keywords:

Flavonoids, multi-target, drug, neurodegenerative, cancer, parasite, inflammation.

Affiliation:

Health Sciences Center, Federal University of Paraíba, Campus I, 58051-970, João Pessoa-PB, State University of Paraíba, Biological Science Department, Laboratory of Synthesis and Drug Delivery, 58070-450, João Pessoa-PB, State University of Paraíba, Biological Science Department, Laboratory of Synthesis and Drug Delivery, 58070-450, João Pessoa-PB, State University of Paraíba, Biological Science Department, Laboratory of Synthesis and Drug Delivery, 58070-450, João Pessoa-PB, Programa de Pós-Graduação em Produtos Naturais e Sintéticos Bioativos, Universidade Federal da Paraíba, João Pessoa, Paraíba 58059-900, Programa de Pós-Graduação em Produtos Naturais e Sintéticos Bioativos, Universidade Federal da Paraíba, João Pessoa, Paraíba 58059-900, Programa de Pós-Graduação em Produtos Naturais e Sintéticos Bioativos, Universidade Federal da Paraíba, João Pessoa, Paraíba 58059-900, Programa de Pós-Graduação em Produtos Naturais e Sintéticos Bioativos, Universidade Federal da Paraíba, João Pessoa, Paraíba 58059-900

Graphical Abstract:



Read Full-Text article