Submit Manuscript  

Article Details


Asymmetric Catalysis in the Synthesis of Azaflavanones

[ Vol. 14 , Issue. 5 ]

Author(s):

Sergio Pinheiro, Estela M.F. Muri, Rafael P. R. F. de Oliveira, Luiza R.S. Dias and Sandro J. Greco   Pages 400 - 406 ( 7 )

Abstract:


Azaflavanones are synthetic aza-analogues of flavanones possessing several biological interests, especially as anticancer. Since individual enantiomers of azaflavanones showed different anticancer activities, the development of asymmetric routes to access this class of compounds has appeared in the literature. This review shows the different approaches for the enantioselective synthesis of azaflavanones based on asymmetric catalysis.

Keywords:

Azaflavanones, Michael, aza-Michael, one-pot reactions, kinetic resolution, enantioselective epoxidation.

Affiliation:

Departamento de Química Orgânica, Instituto de Química, Universidade Federal Fluminense, Outeiro de S. João Batista s/n Centro, Niterói, RJ, Departamento de Tecnologia Farmacêutica, Faculdade de Farmácia, Universidade Federal Fluminense, Rua Mario Viana 523, Santa Rosa, 24241-000, Niterói, RJ, Departamento de Química Orgânica, Instituto de Química, Universidade Federal Fluminense, Outeiro de S. João Batista s/n Centro, Niterói, RJ, Departamento de Tecnologia Farmacêutica, Faculdade de Farmácia, Universidade Federal Fluminense, Rua Mario Viana 523, Santa Rosa, 24241-000, Niterói, RJ, Departamento de Química, Universidade Federal do Espírito Santo, Vitória, ES

Graphical Abstract:



Read Full-Text article