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Thioureas as Building Blocks for the Generation of Heterocycles and Compounds with Pharmacological Activity: An Overview

[ Vol. 15 , Issue. 1 ]

Author(s):

Itamar Luís Goncalves, Gabriel Oliveira de Azambuja, Daniel Fabio Kawano and Vera Lucia Eifler-Lima*   Pages 28 - 35 ( 8 )

Abstract:


Background: Thioureas are widely used as intermediates in organic synthesis, and they are commonly used in several classes of heterocycles.

Objective: There has been an escalating interest in the development of heterocycles employing thioureas as building blocks. Furthermore, thioureas can be utilized as a reagent in a synthesis of a large number of therapeutic agents. In addition, substituted thioureas have recently gained much interest in the preparation of a wide variety of biologically active compounds.

Conclusion: This review highlights the status of thiourea scaffolds in the drug development and heterocyclic synthesis described in the literature mainly since 2010.

Keywords:

Thiourea, heterocyclic synthesis, building blocks, drug design, pharmacological effects, multicomponent reactions.

Affiliation:

Laboratorio de Sintese Organica Medicinal/LaSOM, Programa de Pos-Graduacao em Ciencias Farmaceuticas/ PPGCF, Universidade Federal do Rio Grande do Sul, Av. Ipiranga 2752, 90610-000 Porto Alegre-RS, Laboratorio de Sintese Organica Medicinal/LaSOM, Programa de Pos-Graduacao em Ciencias Farmaceuticas/ PPGCF, Universidade Federal do Rio Grande do Sul, Av. Ipiranga 2752, 90610-000 Porto Alegre-RS, Faculdade de Ciencias Farmaceuticas, Universidade Estadual de Campinas, Rua Sergio Buarque de Holanda 250, 13083-859 Campinas-SP, Laboratorio de Sintese Organica Medicinal/LaSOM, Programa de Pos-Graduacao em Ciencias Farmaceuticas/ PPGCF, Universidade Federal do Rio Grande do Sul, Av. Ipiranga 2752, 90610-000 Porto Alegre-RS

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