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2,3-Dichloro-1,4-Naphthoquinone in Organic Synthesis: Recent Advances

[ Vol. 14 , Issue. 5 ]

Author(s):

Luana da S. M. Forezi, Mariana F. C. Cardoso, Dora C. S. Costa, Fernando de C. da Silva and Vitor F. Ferreira   Pages 375 - 390 ( 16 )

Abstract:


2,3-Dichloro-1,4-naphthoquinone is a special naphthoquinone with four electrophilic sites, useful for applications in organic synthesis and preparation of a diverse new compounds, such as 2,3-substituted derivatives and heterocycles, including those with the core naphthoquinone structure fused. It has also been used for the preparation of compounds for evaluation against several biological targets. This review will describe the most recent applications of 2,3-dichloro-1,4-naphthoquinone in organic synthesis.

Keywords:

Quinones, synthetic applications, biological activity, heterocycles, cyclization reactions, nucleophilic substitutions, napthoquinone.

Affiliation:

Departamento de Química Orgânica, Instituto de Química,Universidade Federal Fluminense, Campus do Valonguinho, 24020-150, Niterói, RJ, Departamento de Química Orgânica, Instituto de Química,Universidade Federal Fluminense, Campus do Valonguinho, 24020-150, Niterói, RJ, Departamento de Química Orgânica, Instituto de Química,Universidade Federal Fluminense, Campus do Valonguinho, 24020-150, Niterói, RJ, Departamento de Química Orgânica, Instituto de Química,Universidade Federal Fluminense, Campus do Valonguinho, 24020-150, Niterói, RJ, Universidade Federal Fluminense, Departamento de Química Orgânica, Programa de Pós- Graduação em Química, Outeiro de São João Baptista, 24020-141 Niterói, RJ

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