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Organocatalytic Synthesis of Spirocarbocycles

[ Vol. 15 , Issue. 5 ]


You-Song Cheng, Shaik Anwar and Kwunmin Chen*   Pages 364 - 373 ( 10 )


The efficient construction of C-C bonds with multiple stereocenters has been of synthetic interest to the synthetic community. This review describes the organocatalytic cascade, domino or tandem synthesis of spirocarbocycles that evolved through the use of small organic catalysts. Spirocarbocycles are frequently observed in organic compounds in nature, and the formation of spirocarbocycles is vital in contemporary organic synthesis. These reactions proceed through the combination of enamine, iminium, dienamine, and trienamine modes of activation to construct multiple C-C bonds with newly generated stereogenic centers.


C-C bonds, organocatalytic, cascade reaction, tandem strategies, spirocarbocycles, enantioselectivity.


Department of Chemistry, National Taiwan Normal University, Taipei, Division of Chemistry, Department of Science and Humanities, Vignan`s Foundation for Science, Technology and Research -VFSTR (Deemed to be University), Vadlamudi, Guntur, Andhra Pradesh, Department of Chemistry, National Taiwan Normal University, Taipei

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