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Transition Metal-Catalyzed Carboxylation of Terminal Alkynes with CO2

[ Vol. 15 , Issue. 4 ]

Author(s):

Chang Qiao, Yu Cao and Liang-Nian He*   Pages 283 - 290 ( 8 )

Abstract:


The coupling reaction of terminal alkynes and CO2 provides a promising way to synthesize propiolic acids. Among the existing catalytic systems, transition-metal copper and silver exhibit excellent catalytic efficiency under mild conditions probably being attributed to the activation of C-C triple bond of terminal alkynes. In this aspect, efficient strategies for activating both substrate and CO2 are often smart choices. This review summarizes the development trend of the Cu/Ag-catalyzed carboxylation reactions of terminal alkynes with CO2, and representative examples are also discussed in detail.

Keywords:

Carbon dioxide, carboxylation, terminal alkyne, propiolic acids, transition metal, catalysis.

Affiliation:

State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University, Nankai Qu, State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University, Nankai Qu, State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University, Nankai Qu

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