Rizk E. Khidre*, Ibrahim Ali M. Radini and Diaa A. Ibrahim Pages 353 - 360 ( 8 )
This review article represents a survey of the synthetic strategies leading to pyrazolyl quinolines. The synthetic methods are divided into two main groups based on the type of starting reagents: 1) From quinoline ring onto a pyrazole scaffold, 2) From pyrazole ring onto a quinoline scaffold. Also, some medical applications of pyrazolyl quinoline derivatives are mentioned such as anticancer, cell proliferative disorder, glucose transport inhibitors, anti-inflammatory, and inhibitors of leukotriene production for the treatment of cardiovascular. The main purpose of this review is to present a survey of the literature on the synthetic approaches of pyrazolyl quinolines and provide useful and up-to-date data for organic and medicinal chemist since such compound has not been previously reviewed.
Pyrazole, quinoline, pyrazolyl quinolones, heterocyclic compounds, carbaldehyde, pyrazole ring.
Chemistry Department, Faculty of Science, Jazan University, Jazan, Chemistry Department, Faculty of Science, Jazan University, Jazan, Chemistry Department, Faculty of Science, Jazan University, Jazan