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Synthetic Approaches of Pyrazolyl Quinolines

[ Vol. 16 , Issue. 4 ]

Author(s):

Rizk E. Khidre*, Ibrahim Ali M. Radini and Diaa A. Ibrahim   Pages 353 - 360 ( 8 )

Abstract:


This review article represents a survey of the synthetic strategies leading to pyrazolyl quinolines. The synthetic methods are divided into two main groups based on the type of starting reagents: 1) From quinoline ring onto a pyrazole scaffold, 2) From pyrazole ring onto a quinoline scaffold. Also, some medical applications of pyrazolyl quinoline derivatives are mentioned such as anticancer, cell proliferative disorder, glucose transport inhibitors, anti-inflammatory, and inhibitors of leukotriene production for the treatment of cardiovascular. The main purpose of this review is to present a survey of the literature on the synthetic approaches of pyrazolyl quinolines and provide useful and up-to-date data for organic and medicinal chemist since such compound has not been previously reviewed.

Keywords:

Pyrazole, quinoline, pyrazolyl quinolines.

Affiliation:

Chemical Industries Division, National Research Centre, Dokki, 12622, Giza, Jazan University Chemistry, Department, Faculty of Science, National Organization for Drug Control & Research, Organic chemistry, P.O. Box: 29, Giza 112313



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