Jonathan E. Kukowski and Irina P. Smoliakova* Pages 323 - 334 ( 12 )
This review covers recent approaches to the synthesis of tertiary phosphines through the C– PR2 (R = alkyl or aryl) bond formation reactions using palladium. The methods include Pd-catalyzed additions of HPR2 to double and triple bonds, substitution and dynamic kinetic resolution of diaryl (pseudo) halide compounds, reactions of cyclopalladated complexes with MPR2 (M = Li or K) or HPR2, intramolecular phosphination, and C–P+ bond cleavages. Together these methods allow for the preparation of diversely functionalized achiral or enantiopure tertiary phosphines for use in organo- and transition metal catalysis among other important applications.
Phosphination, tertiary phosphines, C–P bond formation, C–P coupling, hydrophosphination, dynamic kinetic resolution, cyclopalladated complexes, phosphole synthesis.
Department of Chemistry, University of North Dakota, Grand Forks, ND 58202-9024, Department of Chemistry, University of North Dakota, Grand Forks, ND 58202-9024