Nejib Hussein Mekni* Pages 453 - 462 ( 10 )
Direct substitution and elimination reactions of the fluorine atoms of difluoromethylene CF2α groups of nonspaced perfluoroalkyl chains, CF3 groups are very difficult to achieve. But, they become feasible with fluoro-alkenes, alkynes, imines or carbonyl derivatives, for which vinylic substitution and related carbanion-mediated pathways are available. In this review, we classify the major and unique fluorine substitution/elimination and rearrangement reactions and discuss their contribution to the synthesis of heterocyclic compounds.
Fluorine elimination/substitution, perfluoroalkyl chain, trifluoromethyl, vinylic fluorine, allylic fluorine, organofluorinated compounds.
Department of Chemistry, Faculty of Science, Taibah University, P.O. Box 30002, Al-Munawarah