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Recent Advances and Applications of tert-Butyl Nitrite (TBN) in Organic Synthesis

[ Vol. 17 , Issue. 1 ]


Nader Ghaffari Khaligh*   Pages 3 - 25 ( 23 )


This mini-review will present the recent applications of Tert-Butyl Nitrite (TBN) in organic synthesis. Due to its unique structural feature and wide application, TBN holds a prominent and great potential in organic synthesis. The applications of TBN in three areas viz. aerobic oxidation, annulation, and diazotization were reviewed recently; now, the current mini-review will describe the studies carried out to date in areas such as nitration of alkane, alkene, alkyne, and aromatic compounds, nitrosylation and sequential nitrosylation reactions, using TBN as source of oxygen and nitrogen. The mechanisms of these transformations will be briefly described in this mini-review.


Mechanism, nitration, nitrosylation, organic synthesis, source of nitrogen, source of oxygen, tert-butyl nitrite.


Professor Reza Research Institute, Education Guilan, Rasht, District 1, 41569-17139

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