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Synthetic Approaches to Organoselenium Derivatives with Antimicrobial and Anti-Biofilm Activity

[ Vol. 16 , Issue. 6 ]

Author(s):

Iris Di Leo, Federica Messina, Vanessa Nascimento, Francesca G. Nacca, Donatella Pietrella, Eder J. Lenardão, Gelson Perin and Luca Sancineto*   Pages 589 - 601 ( 13 )

Abstract:


In the recent years, an increasing attention has been given to the biological activities exerted by organoselenium compounds. In 1984, Sies reported for the first time the ability of ebselen to mimic the activity of glutathione peroxidase. From this milestone, several studies reported the pharmacological properties of selenium-containing compounds including their exploitation as antimicrobials. In this context, this minireview presents the most recent examples of seleno derivatives endowed with antimicrobial activities while discussing the most interesting and recent synthetic procedures used to obtain these compounds.

Keywords:

Biofilm, diselenides, gram-negative bacteria, gram-positive bacteria, selenium, benzoisoselenazolones.

Affiliation:

Universidade Federal Fluminense, Departamento de Quimica Organica, Programa de Pos-Graduacao em Quimica, Outeiro de Sao Joao Batista, 24020-141 Niteroi, RJ, Ecotech Group srl Green Chemistry Division, Perugia, Universidade Federal Fluminense, Departamento de Quimica Organica, Programa de Pos-Graduacao em Quimica, Outeiro de Sao Joao Batista, 24020-141 Niteroi, RJ, Department of Pharmaceutical Sciences, University of Perugia, Perugia, Department of Pharmaceutical Sciences, University of Perugia, Perugia, Laboratorio de Síntese Organica Limpa - LASOL, CCQFA, Universidade Federal de Pelotas, P.O. Box 354, 96010-900, Pelotas, RS, Laboratorio de Síntese Organica Limpa - LASOL, CCQFA, Universidade Federal de Pelotas, P.O. Box 354, 96010-900, Pelotas, RS, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363 Lodz

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