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Phytochemical Constituents of Guggul and their Biological Qualities

Author(s):

Vijay Kumar*, Simranjeet Singh and Ravindra Singh   Pages 1 - 12 ( 12 )

Abstract:


Background: In the herbal drug pharmaceutical industry, guggul is enjoying emergent consumer acceptance around the world. In the Indian market, more than fifty formulations of guggul have been introduced by well-known brands including Himalaya, Patanjali and Baidyanath Pharmaceuticals. Basically, guggul is the gum resin from Commiphora wightii (syn. Commiphora Mukul). It has been used to treat various ailments including obesity, osteoarthritis, arthritis, constipation, liver disorders, inflammation, anemia, diabetes etc. Including medicinal properties, it is used as a good binding agent and mixed in various herbal formulations.

Objectives: To review the major phytochemical, medicinal properties and analytical methods involved in the detection of guggul by using the exhaustive bibliographic research by means of various scientific engines and databases.

Conclusion: Guggul contained approximately 66 phytochemical including gallic acid, quercetin, and guggulsterones E and Z. These phytochemicals have a wide range of pharmacological activities such as antioxidant, antibacterial, antimutagenic, antivenom and antitumor. It has been noticed that the mode of action of guggulsterone has not been fully explored. Pharmacology and toxicological studies are very few. These works have shown huge literature gap, which is to be fulfilled through the detailed in-vivo and in-vitro studies.

Keywords:

Cholesterol, commiphora mukul, guggulusterone, obesity, sterols, terpenoids.

Affiliation:

Department of Chemistry, Regional Ayurveda Research Institute for Drug Development, Gwalior (M.P.) - 474009, Department of Biotechnology, Lovely Professional University, Phagwara (Punjab) – 144111, Department of Chemistry, Central Council for Research in Ayurvedic Sciences (CCRAS), New Delhi - 110058



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