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Synthesis and Biological Potentials of Quinoline Analogues: A Review of Literature

[ Vol. 16 , Issue. 7 ]

Author(s):

Leena Kumari, Salahuddin*, Avijit Mazumder, Daman Pandey, Mohammad Shahar Yar*, Rajnish Kumar, Rupa Mazumder, Mohammad Sarafroz, Mohamed Jawed Ahsan, Vivek Kumar and Sushma Gupta   Pages 653 - 688 ( 36 )

Abstract:


Heterocyclic compounds are well known for their different biological activity. The heterocyclic analogs are the building blocks for synthesis of the pharmaceutical active compounds in the organic chemistry. These derivatives show various type of biological activity like anticancer, antiinflammatory, anti-microbial, anti-convulsant, anti-malarial, anti-hypertensive, etc. From the last decade research showed that the quinoline analogs plays a vital role in the development of newer medicinal active compounds for treating various type of disease. Quinoline reported for their antiviral, anticancer, anti-microbial and anti-inflammatory activity. This review will summarize the various synthetic approaches for synthesis of quinoline derivatives and to check their biological activity. Derivatives of quinoline moiety plays very important role in the development of various types of newer drugs and it can be used as lead compounds for future investigation in the field of drug discovery process.

Keywords:

Quinoline, quinoline derivatives, synthetic schemes, Conard-Limpach synthesis, Doebner reaction, Doebner-Miller Reaction Gould-Jacobs reaction, Skraup synthesis.

Affiliation:

Noida Institute of Engineering and Technology (Pharmacy Institute), Plot No. 19, Knowledge Park-2, Greater Noida, Utter Pardesh-201306, Noida Institute of Engineering and Technology (Pharmacy Institute), Plot No. 19, Knowledge Park-2, Greater Noida, Utter Pardesh-201306, Noida Institute of Engineering and Technology (Pharmacy Institute), Plot No. 19, Knowledge Park-2, Greater Noida, Utter Pardesh-201306, Noida Institute of Engineering and Technology (Pharmacy Institute), Plot No. 19, Knowledge Park-2, Greater Noida, Utter Pardesh-201306, Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard University, Hamdard Nagar, New Delhi-110062, Noida Institute of Engineering and Technology (Pharmacy Institute), Plot No. 19, Knowledge Park-2, Greater Noida, Utter Pardesh-201306, Noida Institute of Engineering and Technology (Pharmacy Institute), Plot No. 19, Knowledge Park-2, Greater Noida, Utter Pardesh-201306, Department of Pharmaceutical Chemistry, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, City Dammam, Department of Pharmaceutical Chemistry, College of Pharmacy, King Khalid University, Abha 62529, Noida Institute of Engineering and Technology (Pharmacy Institute), Plot No. 19, Knowledge Park-2, Greater Noida, Utter Pardesh-201306, Noida Institute of Engineering and Technology (Pharmacy Institute), Plot No. 19, Knowledge Park-2, Greater Noida, Utter Pardesh-201306



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