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Application of Transition Metals in Sulfoxidation Reactions

Author(s):

Qiang Pu, Mosstafa Kazemi* and Masoud Mohammadi   Pages 1 - 26 ( 26 )

Abstract:


Sulfoxides are key scaffolds in the synthesis of pharmaceutically active molecules. A large number of sulfoxides are an indispensable ingredient in the structure or building of most of antibiotics, biological and natural products such as Modafinil, Adrafinil, CRL-40,941 or fladrafinil, Fipronil, Oxydemeton-methyl, Omeprazole, Pantoprazole, Lansoprazole and Rabeprazole. The oxidation of sulfides is the most common and most efficient strategy for the preparation of sulfoxides. In recent times, many protocols based on using transition metals have been reported for the oxidation of sulfides to the sulfoxides. In this paper, we summarized a nice category of reported protocols in literature for the oxidation sulfides to sulfoxides.

Keywords:

Sulfoxides, Oxidation of sulfides, Transition metals, Antibiotics, Natural products

Affiliation:

School of Information Science and Engineering, Chengdu University, Chengdu 610106, Department of Chemistry, Faculty of Basic Sciences, Ilam University, P.O. Box 69315-516, Ilam, Department of Chemistry, Faculty of Basic Sciences, Ilam University, P.O. Box 69315-516, Ilam



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