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Multicomponent Catalytic Synthesis of 1,5-Benzodiazepines: An Update

Author(s):

Rajesh K. Singh*, Sadhna Sharda, Shikha Sharma, Sahil Kumar and Deo Nandan Prasad   Pages 1 - 19 ( 19 )

Abstract:


1,5-Benzodiazepines are considered one of the most vital classes of heterocyclic compounds due to their amazing biological and varied pharmacological activities. They are regarded as privileged structures and therefore have been striking synthetic target for organic and medicinal chemists over the last decade. This consequences in the exploration of various silica supported catalysts, Lewis acids, organoacids, magnetic nanoparticles and other miscellaneous catalysts that have been investigated till date for an efficient and green synthesis of 1,5-benzodiazepine and its derivatives. The current review article primarily covers the one-pot green chemical synthesis for the synthesis of 1,5-benzodiazepines using various novel catalysts. The main motive of this review is to present a survey of the literature on various catalysts alongwith their yield, reaction condition and mechanism of action. In the end, the entire catalysts are organized systematically into various Lewis acids, Bronsted organoacids, supported catalysts, nanocatalysts and miscellaneous catalysts and are presented in the form of tables for quick at a glance study of catalysts, their reaction condition, time taken etc.

Keywords:

1, 5-benzodiazepines, green catalyst, Lewis catalyst, organoacids, silica-supported catalyst, magnetic nanoparticles

Affiliation:

Department of Pharmaceutical Chemistry, Shivalik College of Pharmacy, Nangal, Dist. Rupnagar, 140126, Punjab, Department of Pharmaceutical Chemistry, Lovely Professional University, Phagwara, 144411, Punjab, Department of Pharmaceutical Chemistry, Global College of Pharmacy, Kahnpur-Khui, Dist. Ropar, Punjab, Department of Pharmacy, School of Medical and Allied Sciences, GD Goenka University, Sohna, Dist. Gurugram-122103, Haryana, Department of Pharmaceutical Chemistry, Shivalik College of Pharmacy, Nangal, Dist. Rupnagar, 140126, Punjab



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