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Synthetic Approach for Substituted 3-amino-1,2,4-triazines and their Chemical Reactivity and Biological Properties

Author(s):

Reda Abdel Rahman , Mohammed A. Assiri, Ahmed M. Fouda and Tarik E. Ali*   Pages 1 - 20 ( 20 )

Abstract:


3-Amino-1,2,4-triazines are considered versatile compounds for its significance as building blocks in synthetic and pharmaceutical chemistry. The synthesis, chemical reactivity, and applications of substituted 1,2,4-triazines bearing an amino group were described in this review. The presence of the amino group at position 3 exhibited unique reactivities towards carbonitrile, carbonyl and isothiocyanate reagents. The reactions were divided into several categories, depending on the other substituents on the 1,2,4-triazine ring. In this review, relevant and appropriate applications of the synthesized, isolated, and condensed heterocycles derivatives were reported.

Keywords:

Synthesis, 3-amino-1, 4-triazines, reactivity, pharmacological., chemical reactivity

Affiliation:

Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah, Department of Chemistry, Faculty of Science, King Khalid University, Abha, Department of Chemistry, Faculty of Science, King Khalid University, Abha, Department of Chemistry, Faculty of Science, King Khalid University, Abha



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