Zaib Un Nisa and Tashfeen Akhtar* Pages 1 - 15 ( 15 )
PABA (p-aminobenzoic acid) is an important substrate for the synthesis of various biological scaffolds. Its pharmacological significance is apparent form the drugs like folic acid and benzocaine, which are used for certain biological disorders. Although it is not a vitamin but still it is referred as a member of vitamin B. The deficiency of PABA leads to several disorders like erratic white areas of skin, grey hair, fatigue, depression and irritability. Besides the its medicinal importance, PABA has been used in the synthesis of various biologically active heterocyclic nuclei like benzimidazoles, azitidinones, thiazolidinones, pyrazoline, etc. This review will describe the applications of PABA in the synthesis of these biologically active nuclei and hence emphasizing its importance as a versatile substrate.
amino benzoic acid, diazoles, imidazoles, azetidinone
Department of Chemistry, Mirpur University of Science and Technology (MUST) 10250 Mirpur (AJK),, Department of Chemistry, Mirpur University of Science and Technology (MUST) 10250 Mirpur (AJK)