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Novel Ketosynthases Catalyzing the Non-Decarboxylative Claisen Condensation

[ Vol. 17 , Issue. 2 ]


Lixia Pan and Dengfeng Yang*   Pages 169 - 175 ( 7 )


In this review, we present the recent advances in unusual novel ketosynthases catalyzing the non-decarboxylative Claisen condensations, including CsyB, MxnB/CorB, Ppys and StlD. The differences are summarized between these non-decarboxylative ketosynthases and the typical decarboxylative ketosynthases. Furthermore, the detailed enzymatic characteristics, structural basis, and catalytic mechanismof these novel ketosynthasesare described. Finally, the prospect of these kind of ketosynthases is discussed.


Catalytic mechanism, claisen condensation, condensation reaction head-to-head condensation, novel ketosynthases, polyketide synthase, decarboxylative enzymes.


Guangxi Key Laboratory of Biorefinery, Guangxi Biomass Industrialization Engineering Institute, National Engineering Research Center of Non-food Biorefinery, State Key Laboratory of Non-Food Biomass and Enzyme Technology, Guangxi Academy of Sciences, Nanning 530007, Guangxi, Guangxi Key Laboratory of Marine Natural Products and Combinatorial Biosynthesis Chemistry, Guangxi Beibu Gulf Marine Research Center, Guangxi Academy of Sciences, Nanning 530007, Guangxi

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