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Coumarin-Oxadiazole Derivatives: Synthesis and Pharmacological Properties

[ Vol. 17 , Issue. 7 ]

Author(s):

Nurhayatun S. Abdul Razak, Joazaizulfazli Jamalis*, Subhash Chander, Roswanira Abdul Wahab, Deepak P. Bhagwat, Terry K. Smith and Murugesan Sankaranarayanan   Pages 780 - 794 ( 15 )

Abstract:


Coumarin and oxadiazole moieties ubiquitously occur in a wide range of natural products and are valued for their varied and beneficial pharmacological activities. Herein, this review focuses on various documented techniques used by researchers to synthesize an assortment of biologically active coumarin-oxadiazole scaffolds. Also, the common techniques discussed are used to establish the wide-range of biological activities of the synthesized coumarin and oxadiozole derivatives, including; antioxidant, anthelmintic, antimicrobial, anti-tuberculosis, analgesic, anti-inflammatory, cytotoxicity and anticonvulsant. Additionally, the current, well-established drugs synthesized using coumarin-oxadiazole scaffolds are typically dispensed in regular clinical practice are also highlighted in this review paper.

Keywords:

Biological activities, coumarin-oxadiazole, coumarins, drugs, oxadiazoles, synthesis.

Affiliation:

Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, Johor Bahru 81310, Johor, Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, Johor Bahru 81310, Johor, School of Pharmacy, Maharaja Agrasen University, Atal Shiksha Kunj, Village Kalujhanda, Solan-174103, Himachal Pradesh, Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, Johor Bahru 81310, Johor, School of Pharmacy, Maharaja Agrasen University, Atal Shiksha Kunj, Village Kalujhanda, Solan-174103, Himachal Pradesh, Schools of Biology & Chemistry, BSRC, The University, St. Andrews, Fife Scotland, KY16 9ST, Medicinal Chemistry Research Laboratory, Department of Pharmacy, Birla Institute of Technology & Science Pilani, Pilani Campus, Pilani-333031, Rajasthan

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