Biswanath Das*, Nayaki Salvanna, Rathod Aravind Kumar and Ratna Das Pages 843 - 854 ( 12 )
Parthenium hysterophorus (Compositae), an obnoxious weed, was investigated thoroughly for its chemical constituents. We isolated a large number of pseudoguaianolides and other compounds. Many of the isolates are new natural products. Parthenin, the major pseudoguaianolide, was synthetically converted to its various analogues. Some of the constituents of the plant and of the prepared analogues were found to possess significant antibacterial and anticancer properties. Here, we review our phytochemical research on Parthenium hysterophorus informing of our work on the isolation, structure elucidation, synthetic modifications, and bioevaluation of its chemical constituents.
Bioactivity, chemistry, natural constituents, Parthenium hysterophorus, phytochemical investigation, structure elucidation, synthetic conversion.
Natural Products Chemistry Division, CSIR- Indian Institute of Chemical Technology, Hyderabad 500007, Osmania University Post Graduate College, Narsapur, Medak, Telangana -502 313, Natural Products Chemistry Division, CSIR- Indian Institute of Chemical Technology, Hyderabad 500007, Deparment of Chemistry, Gurudas College, Calcutta University, Narkeldanga Main Road, Kolkata, West Bengal 700 054