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Δα,β-Butenolides [Furan-2(5H)-ones]: Ring Construction Approaches and Biological Aspects - A Mini-Review

[ Vol. 17 , Issue. 8 ]

Author(s):

Andrés-Felipe Villamizar-Mogotocoro, Andrés-Felipe León-Rojas and Juan-Manuel Urbina-González*   Pages 922 - 945 ( 24 )

Abstract:


The five-membered oxacyclic system of furan-2(5H)-ones, commonly named as γ- butenolides or appropriately as Δα,β-butenolides, is of high interest since many studies have proven its bioactivity. During the past few years, Δα,β-butenolides have been important synthetic targets, with several reports of new procedures for their construction. A short compendium of the main different synthetic methodologies focused on the Δα,β-butenolide ring formation, along with selected examples of compounds with relevant biological activities of these promising pharmaceutical entities is presented.

Keywords:

Δα, β-butenolide, butenolactone, furan-2(5H)-one, isocrotonolactone, unsaturated γ lactone, γ-butenolide.

Affiliation:

School of Chemistry, Faculty of Science, Universidad Industrial de Santander, Bucaramanga, Department of Organic Chemistry, Faculty of Chemistry, Universidad Nacional Autónoma de México, México D.F., School of Chemistry, Faculty of Science, Universidad Industrial de Santander, Bucaramanga

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