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A Review on the Synthesis and Biological Studies of 2,4-Thiazolidinedione Derivatives

[ Vol. 17 , Issue. 8 ]

Author(s):

Srinivasa Reddy Bireddy*, Veera Swamy Konkala, Chandraiah Godugu and Pramod Kumar Dubey   Pages 958 - 974 ( 17 )

Abstract:


2,4-Thiazolidinediones are versatile scaffolds with a unique structural feature of hydrogen bonding donor and the hydrogen bonding acceptor region. This review deals with the synthesis of various bio-active 2,4-thiazolidinedione derivatives. It is presented on the basis of the linker variations at 3rd & 5th positions of 2,4-thizolidinediones. Biological evaluations of various derivatives thus prepared and toxicity studies on the respective products as given by various researchers/ Research groups have been described.

Keywords:

2, 4-Thiazolidinediones, antidiabetic activity, glitazones, Knoevenagel condensation, acid hydrolysis, type-2 diabetes.

Affiliation:

Department of Chemistry, Mahatma Gandhi Institute of Technology, Gandipet, Hyderabad-500 075, Department of Chemistry, Jawaharlal Nehru Technological University, College of Engineering, Kukatpally, Hyderabad- 500 085, Department of Regulatory Toxicology, National Institute of Pharmaceutical Educational Research Balanagar, Hyderabad-500 037, Department of Chemistry, Jawaharlal Nehru Technological University, College of Engineering, Kukatpally, Hyderabad- 500 085

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