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One-Pot Multicomponent Synthesis of Imidazole Rings in Acidic Ionic Liquids: A Review

[ Vol. 17 , Issue. 8 ]

Author(s):

Cosmas Chinweike Eze*, Mercy Amarachi Ezeokonkwo, Benjamin Ebere Ezema, Abraham Efeturi Onoabedje, Fidelia Ngozika Ibeanu, David Izuchukwu Ugwu, Leonard Ebuka Onyeyilim and James Anayochwkwu Ezugwu   Pages 975 - 990 ( 16 )

Abstract:


The design of the environmentally friendly approach to the synthesis of biologically important compounds without compromising the yield has been the focus of many chemists in recent years. The development of the one-pot synthesis of heterocycles in the presence of Ionic Liquids (ILs), used as both environmental media and catalysts, is efficient and environmentally sustainable. This review highlights the one-pot synthesis of imidazoles in acidic ILs in the past decade. Some reviews have been conducted on imidazoles, such as their pharmacological importance. Hence, we decided to focus on their synthesis in acidic ionic liquids, which the authors are not aware of any published literature.

Keywords:

Environmental sustainability, imidazole, ionic liquids, multicomponent, one-pot synthesis, organic synthesis.

Affiliation:

Natural Science Unit, School of General Studies, University of Nigeria, Nsukka, Enugu State 410001, Department of Pure & Industrial Chemistry, University of Nigeria, Nsukka, Enugu State 410001, Department of Pure & Industrial Chemistry, University of Nigeria, Nsukka, Enugu State 410001, Department of Pure & Industrial Chemistry, University of Nigeria, Nsukka, Enugu State 410001, Natural Science Unit, School of General Studies, University of Nigeria, Nsukka, Enugu State 410001, Department of Pure & Industrial Chemistry, University of Nigeria, Nsukka, Enugu State 410001, Department of Pure & Industrial Chemistry, University of Nigeria, Nsukka, Enugu State 410001, Department of Pure & Industrial Chemistry, University of Nigeria, Nsukka, Enugu State 410001

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