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Synthetic Strategies for the (+)-Grandisol, the Main Constituent of Boll Weevil Pheromone

[ Vol. 18 , Issue. 6 ]

Author(s):

Krysthal Marrie dos Santos, Jorge de Lima Neto, Luis Paulo Alves da Silva, Analú Campos Reis, Ricardo Silva Porto, Dimas José da Paz Lima and Antônio Euzébio Goulart Santana*   Pages 690 - 708 ( 19 )

Abstract:


This paper presents a short review of synthetic approaches aiming to synthesise (+)- Grandisol, the main constituent of grandlure, a pheromone mixture released by the boll weevil, which is proven to exhibit significant biological activity. (+)-Grandisol 1 is among the components of the male-produced pheromone of the boll weevil Anthonomuns grandis, an important pest of cotton crops in Mesoamerica (from the south USA to Argentina). As a result of its biological activity and unique structure, several synthetic approaches have been reported. The aim is to explore remarkable methodologies towards the synthesis of (+)-Grandisol 1. Several methodologies have been applied towards the synthesis of (+)-Grandisol 1, including classical methods for cyclobutane ring construction, which promoted substantial improvements to access this pheromone, as well as a better comprehension of its biological profile.

Keywords:

Pheromone, (+)-grandisol, [2 + 2] cycloaddition, boll weevil, Anthonomus grandis Boh, cyclobutane ring systems.

Affiliation:

Chemistry and Biotechnology Institute, Federal University of Alagoas, Maceio, Chemistry and Biotechnology Institute, Federal University of Alagoas, Maceió, Chemistry and Biotechnology Institute, Federal University of Alagoas, Maceió, Chemistry and Biotechnology Institute, Federal University of Alagoas, Maceió, Chemistry and Biotechnology Institute, Federal University of Alagoas, Maceió, Chemistry and Biotechnology Institute, Federal University of Alagoas, Maceió, Center of Engineering and Agrarian Science, Federal University of Alagoas, Rio Largo

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