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The Synthesis and Chemistry of 2-Imino-2H-Chromene-3-Carbo(Thio) Amides

[ Vol. 18 , Issue. 6 ]

Author(s):

Tarik E. Ali*, Hafez M. El-Shaaer, Somaia M. Abdel-Kariem, Mai S. A. Hussien, Ibrahim S. Yahia and Heba Y. Zahran   Pages 786 - 807 ( 22 )

Abstract:


2-Imino-2H-chromene-3-carbo(thio)amides are considered versatile compounds because of their significance as building blocks in synthetic chemistry. In this review, we display all the available synthetic methods for 2-imino-2H-chromene-3-carbo(thio)amides as well as their reactions towards the different reagents. The presence of the imino and amide groups in these compounds makes C-4 the only reactive site of the pyran ring with a unique reactivity that could react with different reagents. The appropriate applications for the synthesis of condensed chromene derivatives and their relevancy are reported. The reactions of 2-imino-2H-chromene-3- carbo(thio)amides were divided into several categories depending on the used reagents in the reactions.

Keywords:

Chromene, imino, amide, synthesis, reactivity, cyclization, nucleophiles, electrophiles.

Affiliation:

Department of Chemistry, Faculty of Science, King Khalid University, Abha, Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, Cairo, Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, Cairo, Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, Cairo, Research Center for Advanced Materials Science (RCAMS), King Khalid University, Abha, Research Center for Advanced Materials Science (RCAMS), King Khalid University, Abha

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