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Review on the Synthetic Methods of Biologically Potent Benzoxazole Derivatives

[ Vol. 18 , Issue. 6 ]

Author(s):

Subramaniyan Arulmurugan, Helen P. Kavitha* and Jasmine P. Vennila   Pages 769 - 785 ( 17 )

Abstract:


Benzoxazole compounds have an important and broad range of biological activities. The benzoxazole and its substituted derivatives possess antimicrobial, antitumor, anti-inflammatory, antihistaminic, anti-parasitic, herbicidal, anti-allergic, anti-helmintic, anti-tubercular, anticonvulsant, hypoglycaemic, HIV-1 reverse transcriptase inhibitor and insecticidal activities. It has also been shown to have a binding affinity to Aβ42 fibrils. Such complex biological uses of benzoxazole compounds have inspired new efforts to find new derivatives with improved biological activity and different applications in the pharmaceutical industry. Due to outstanding relevance of this structure, the purpose of this analysis is to highlight aspects published in recent years (2000-2020) on the chemistry and biological activity of benzoxazoles.

Keywords:

Benzoxazole, synthesis, antimicrobial activity, anti-inflammatory activity, anticancer activity, antitubercular activity.

Affiliation:

Department of Chemistry, SRM Institute of Science and Technology, Ramapuram Campus, Bharathi Salai, Ramapuram, Chennai, Tamil Nadu, Department of Chemistry, SRM Institute of Science and Technology, Ramapuram Campus, Bharathi Salai, Ramapuram, Chennai, Tamil Nadu, Department of Physics, Panimalar Institute of Science and Technology, Chennai, Tamil Nadu

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