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Insight View on Synthetic Strategies and Biological Applications of Pyrimidobenzothiazoles

[ Vol. 18 , Issue. 8 ]

Author(s):

Dinesh Kumar Agarwal, Nusrat Sahiba, Ayushi Sethiya, Jay Soni, Pankaj Teli, Shikha Agarwal* and Pradeep Kumar Goyal   Pages 1012 - 1025 ( 14 )

Abstract:


Pyrimidobenzothiazoles and its derivatives are important structural scaffolds in the field of synthetic organic chemistry and medicinal chemistry. The review is focused on one pot multicomponent approaches for generating pyrimidobenzothiazoles and its derivatives along with their interesting biological profile over the last ten years. Several eco-benign and cost effective approaches such as nano catalyst, ionic liquid, metal, solid acid, catalyst free, solvent free, etc. for its synthesis have been discussed in this review. Different synthetic strategies of pyrimidobenzothiazole derivatives have been compiled and discussed using 2-aminobenzothiazole, 1,3 diketones, substituted aldehydes, alkynoic acid, bis-methyl thiomethylene malononitrile, Baylis Hillman acetates, etc.

Keywords:

2-aminobenzothiazole, multicomponent reaction, pyrimidobenzothiazole, synthetic approaches, biological profile, substituted aldehydes.

Affiliation:

Department of Pharmacy, B. N. University, Udaipur, 313001, Synthetic Organic Chemistry Laboratory, Department of Chemistry, MLSU, Udaipur, 313001, Synthetic Organic Chemistry Laboratory, Department of Chemistry, MLSU, Udaipur, 313001, Synthetic Organic Chemistry Laboratory, Department of Chemistry, MLSU, Udaipur, 313001, Synthetic Organic Chemistry Laboratory, Department of Chemistry, MLSU, Udaipur, 313001, Synthetic Organic Chemistry Laboratory, Department of Chemistry, MLSU, Udaipur, 313001, Department of Pharmacy, B. N. University, Udaipur, 313001

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