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Recent Trend in the Chemistry of Triazolopyrimidines and their Applications

[ Vol. 18 , Issue. 8 ]

Author(s):

Mounir A. Salem, Mohamed S. Behalo and Rizk E. Khidre*   Pages 1134 - 1149 ( 16 )

Abstract:


This review deals with the synthetic methods, chemical reactions, and applications of triazolopyrimidine derivatives. The synthetic methods and chemical reactions are subdivided into groups according to the junction between triazole and pyrimidine moieties for instance [1,2,4]triazolo[1,5- a]pyrimidine, [1,2,4]triazolo[1,5-c]pyrimidine, [1,2,3]triazolo[1,5-a]pyrimidine, [1,2,3]triazolo[1,5- c]pyrimidine, [1,2,4]triazolo[4,3-c]pyrimidine, and [1,2,4]triazolo[4,3-a]pyrimidine. Pharmacological activity of triazolopyrimidins is also reported.

Keywords:

Triazolopyrimidine, pyrimidine, triazole, synthesis, heterocycles, pharmacological activities.

Affiliation:

Chemistry Department, Synthetic Heterocycles Laboratory, Faculty of Science, Ain Shams University, P. O. Box 11566, Cairo, Chemistry Department, Faculty of Science, Benha University, P. O. Box 13518, Benha, Chemistry Department, Faculty of Science, Jazan University, Jazan

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